Delayed release dexlansoprazole in the treatment of GERD and erosive esophagitis
نویسندگان
چکیده
منابع مشابه
Dexlansoprazole Delayed Release: pharmacotherapy of erosive esophagitis and GeRD
Dexlansoprazole MR is a modified release formulation of the R-enantiomer of lansoprazole, which employs a novel Dual Delayed Release (DDR) technology. Pharmacokinetic studies have shown that the DDR technology provides a two peaks drug release, accuring 1–2 hours and 4–5 hours after dosing, leading to an extended duration of therapeutic plasma drug concentrations compared with conventional dela...
متن کاملDelayed release dexlansoprazole in the treatment of GERD and erosive esophagitis
Although proton pump inhibitors (PPI) have a record of remarkable effectiveness and safety in the management of gastroesophageal reflux disease (GERD), several treatment challenges with PPI have emerged. Dexlansoprazole MR is the (R)-enantiomer of lansoprazole contained in a formulation that produces two distinct releases of drug and significantly extends the duration of active plasma concentra...
متن کاملDexlansoprazole for the treatment of esophagitis and GERD.
Occasional acid reflux occurs frequently in the general population but gastroesophageal reflux disease (GERD), a chronic disease that affects millions of adults and children, is diagnosed if persistent reflux occurs more than twice a week. The development of proton pump inhibitors (PPIs) dramatically improved the treatment of GERD; however, the treatment of patients with refractory GERD remains...
متن کاملThe role of dexlansoprazole modified-release in the management of gastroesophageal reflux disease.
Dexlansoprazole modified-release (MR) is the R-enantiomer of lansoprazole and is currently the only proton-pump inhibitor (PPI) with a novel dual delayed release (DDR) formulation. Overall, dexlansoprazole MR demonstrates a similar safety and side-effect profile as lansoprazole. Dexlansoprazole MR has been shown to be highly efficacious in healing erosive esophagitis, maintaining healed esophag...
متن کاملManagement of gastroesophageal reflux disease and erosive esophagitis in pediatric patients: focus on delayed-release esomeprazole
OBJECTIVE To review the literature on the treatment of gastroesophageal reflux disease (GERD) with emphasis on proton pump inhibitors (PPIs), particularly on delayed-release esomeprazole, and to identify properties and adverse effects of PPIs observed in the treatment of GERD in children and adolescents. SOURCES Electronic search of PubMed/Medline and Cochrane Collaboration databases, and of ...
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ژورنال
عنوان ژورنال: Clinical and Experimental Gastroenterology
سال: 2009
ISSN: 1178-7023
DOI: 10.2147/ceg.s5765